Our Plasmid DNA Technology

At Novel Bio, our proprietary technology ecosystem accelerates plasmid DNA production for a diverse range of partners, including those in therapeutics and healthcare, biological research, food and agriculture, and other synthetic biology applications.

Whether you’re partnering with us through our high-performance service model or integrating our tools directly into your own lab, our plasmid DNA technology delivers unmatched speed, scalability, and precision. From plasmid design to delivery, we offer technology solutions that empower you to move faster, and with greater confidence, from lab to clinic. 


Higher yield

Half the time

Higher quality

Lower endotoxins

Compatible with E. coli infrastructure

Scalable to large-scale pDNA production

NBx Platform™

Through our proprietary microbial system, the NBx Platform, we deliver high-throughput plasmid DNA production as a part of our full-service offering, offering higher yields, shorter run times, and better quality than standard E. coli systems. It’s one of several technologies we’ve developed and utilized that gives us a distinct edge in speed, scalability, and scientific precision. 



NBx Cyclone™

For teams looking to bring this performance in-house, NBx Cyclone enables high-throughput, small-scale plasmid DNA experiments, helping scientists iterate faster, optimize workflows, and generate reliable data directly from their own lab.



Technologies Powering Our Full-Service Model

In addition to NBx, we leverage a suite of plasmid DNA technologies that support the pharmaceutical drug development process—as well as applications in healthcare, biological research, food and agriculture, and other synthetic biology applications. These technologies help us reduce cycle times, create faster plasmid design iterations and enable most consistent reproducibility. 

Our Technologies & Capabilities

  • DNA design software

  • State-of-the-art DNA assembly techniques  

  • Non-E. Coli-based platforms for plasmid DNA cloning and production

  • E. coli-based platforms both traditional (e.g., DH5α) and proprietary E. coli strains

  • Cell-free DNA production technologies

  • Technologies for large plasmid production (>100 kb)

  • Analysis tools

  • A variety of DNA sequencing modalities (Sanger, short-read NGS, long-read NGS)

  • Capable of supporting our clients with bioinformatic analysis

  • Complete plasmid DNA QC

    • Purity

    • Appearance

    • Identity and DNA homogeneity (predominantly supercoiled)

    • Endotoxin  testing

    • Concentration specification

    • Restriction digest

    • NGS and Sanger sequencing

  • Strain engineering

  • Upstream and downstream process development powered by systematic statistical frameworks for experimental optimization.

  • Significant strain engineering experience across a variety of industrially relevant species